Generalized Wegener's granulomatosis responding to sulfamethoxazole-trimethoprim monotherapy

Citation
T. Ohtake et al., Generalized Wegener's granulomatosis responding to sulfamethoxazole-trimethoprim monotherapy, INTERN MED, 40(7), 2001, pp. 666-670
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
0918-2918 → ACNP
Volume
40
Issue
7
Year of publication
2001
Pages
666 - 670
Database
ISI
SICI code
0918-2918(200107)40:7<666:GWGRTS>2.0.ZU;2-Y
Abstract
Wegener's granulomatosis (WG) has two different clinical phases: the initia l phase and generalized phase. In patients with generalized WG, both steroi ds and cyclophosphamide have generally been used. We report a case of gener alized WG that was temporarily, but successfully treated with sulfamethoxaz ole-trimethoprim (S/T) alone. S/T therapy reduced the elevated levels of so luble IL-2 receptor and IL-6 in parallel with improvement of the patient's symptoms and urinary protein excretion. In view of the high incidence of le thal adverse effects of cytotoxic drugs, S/T monotherapy may be worth tryin g not only for initial phase WG but also for generalized WG with careful fo llow-up when the patient is not acutely ill.