Myelitis associated with atopic disorders in Japan: a retrospective clinical study of the past 20 years

Citation
J. Kira et al., Myelitis associated with atopic disorders in Japan: a retrospective clinical study of the past 20 years, INTERN MED, 40(7), 2001, pp. 613-619
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
0918-2918 → ACNP
Volume
40
Issue
7
Year of publication
2001
Pages
613 - 619
Database
ISI
SICI code
0918-2918(200107)40:7<613:MAWADI>2.0.ZU;2-8
Abstract
Objective To clarify the clinical features of myelitis associated with atop ic disorders in Japanese patients. Subjects and Methods We retrospectively studied the clinical, immunological and electrophysiological features of 68 consecutive patients with myelitis of acute or subacute onset diagnosed at Kyushu University Hospital during the past 20 years. Results While only 2 of 28 (7%) patients with myelitis diagnosed between 19 79 and 1993 had either atopic dermatitis (AD) or bronchial asthma (BA), 19 of 40 (48%) patients with myelitis diagnosed between 1994 and 1998 did. Amo ng the 40 patients with myelitis diagnosed between 1994 and 1998, 19 patien ts with either AD or BA as well as 21 patients without either disease showe d a significantly higher level of serum total IgE, higher frequency of hype rIgEaemia and higher frequency of mite antigen-specific IgE than 82 healthy controls. Myelitis patients with AD presenting as persistent paresthesia/d ysesthesia in all four limbs showed cervical cord lesions on MRI and abnorm alities in upper limb motor evoked potentials but no abnormalities in the c erebrospinal fluid (CSF), while myelitis patients with BA showed preferenti al involvement of the lower motor neurons clinically and electromyographica lly. In addition, 12 patients with myelitis who had hyperIgEaemia and mite antigen-specific IgE but neither AD nor BA showed incomplete transverse mye litis with mild motor disability and few CSF abnormalities. Conclusion The clinical features of myelitis associated with atopic disorde rs were in part distinguished by the type of preceding atopic disorder, and also were different from those of hyperIgEaemic myelitis with no preceding atopic disorders.