Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining

Citation
Y. Moriwaki et al., Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining, HIST HISTOP, 16(3), 2001, pp. 745-753
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
HISTOLOGY AND HISTOPATHOLOGY
ISSN journal
0213-3911 → ACNP
Volume
16
Issue
3
Year of publication
2001
Pages
745 - 753
Database
ISI
SICI code
0213-3911(200107)16:3<745:WCDOAO>2.0.ZU;2-Q
Abstract
Aldehyde oxidase (EC 1.2.3.1) is a xenobiotic metabolizing enzyme that cata lyzes a variety of organic aldehydes and N-heterocyclic compounds. However, its precise pathophysiological function in humans, other than its xenobiot ic metabolism, remains unknown. In order to gain a better understanding of the role of this enzyme, it is important to know its exact localization in human tissues. In this study, we investigated the distribution of aldehyde oxidase at the cellular level in a variety of human tissues by immunohistoc hemistry. The enzyme was found to be widespread in respiratory, digestive, urogenital, and endocrine tissues, though we also observed a cell-specific localization in the various tissues studied. In the respiratory system, it was particularly abundant in epithelial cells from the trachea and bronchiu m, as well as alveolar cells. In the digestive system, aldehyde oxidase was observed in surface epithelia of the small and large intestines, in additi on to hepatic cells. Furthermore, the proximal, distal, and collecting tubu les of the kidney were immunostained with various intensities, while glomer ulus tissues were not. In epididymus and prostate tissues, staining was obs erved in the ductuli epididymidis and glandular epithelia. Moreover, the ad renal gland, cortex, and notably the zona reticularis, showed strong immuno staining. This prevalent tissue distribution of aldehyde oxidase in humans suggests some additional pathophysiological functions besides xenobiotic me tabolism. Accordingly, some possible roles are discussed.