Biogenic amines modulate olfactory receptor neurons firing activity in Mamestra brassicae

Citation
X. Grosmaitre et al., Biogenic amines modulate olfactory receptor neurons firing activity in Mamestra brassicae, CHEM SENSE, 26(6), 2001, pp. 653-661
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary,"Neurosciences & Behavoir
Journal title
CHEMICAL SENSES
ISSN journal
0379-864X → ACNP
Volume
26
Issue
6
Year of publication
2001
Pages
653 - 661
Database
ISI
SICI code
0379-864X(200107)26:6<653:BAMORN>2.0.ZU;2-I
Abstract
The modulatory effects of the biogenic amines octopamine and serotonin on p heromonal receptor neurons of Mamestra brassicae were investigated. The res ponses to sex pheromone components of two cells types (A and B) in single m ale long sensilla trichodea were monitored. Cell types A and B do not respo nd to the same compound. The response of type A to a pulse of the major sex pheromone component increased 5 min after octopamine injection. Responses of type B to other odorants increased after 30 min. In the absence of any p heromone stimulation the background firing activity of type A increased fol lowing octopamine injection. This background activity was used to evaluate the kinetics of octopamine and other biogenic amine effects on olfactory re ceptor neurons. Octopamine increased this background activity in a concentr ation- and time-dependent manner. Clonidine, an octopamine agonist, was sho wn to be more powerful in increasing the background activity of olfactory r eceptor neurons. The effects of octopamine and clonidine were hypothesized to arise from specific receptor activation as chlorpromazine (an octopamine antagonist) was shown to block the effect of octopamine. Serotonin, a know n neuromodulator in most animal species, induced a reversible inhibition of spike firing. Altogether, these results indicate that biogenic amines can modulate the sensitivity of olfactory receptor neurons of moths either dire ctly or by an action on adaptation.