Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells

Citation
Ml. Schroeter et al., Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells, NEUROREPORT, 12(11), 2001, pp. 2513-2517
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
12
Issue
11
Year of publication
2001
Pages
2513 - 2517
Database
ISI
SICI code
0959-4965(20010808)12:11<2513:AIMSDI>2.0.ZU;2-E
Abstract
Astrocytes induce blood-brain barrier (BBB) proper-ties in brain endothelia l cells (EC). O-2, generated in blood and EC, opens the BBB. Hence, high ac tivity of superoxide dismutase (SOD) is a prerequisite for normal BBB funct ion. Therefore, the influence of rat astrocytes on the expression of mangan ese (Mn)SOD in rat EC was investigated in two coculture models of the BBB, allowing either exchange of soluble factors or additionally cellular contac ts, Activity, protein content and mRNA expression of endothelial MnSOD were significantly increased in both coculture models in comparison to monocult ure by soluble astrocytic factors, such as cytokines. High activity of endo thelial MnSOD may be considered as a further essential property of the BBB, which is induced and maintained by astrocytes. NeuroReport 12:2513-2517 (C ) 2001 Lippincott Williams & Wilkins.