Effect of hypothermia on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet

Citation
Ws. Park et al., Effect of hypothermia on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet, NEUROCHEM R, 26(4), 2001, pp. 369-374
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROCHEMICAL RESEARCH
ISSN journal
0364-3190 → ACNP
Volume
26
Issue
4
Year of publication
2001
Pages
369 - 374
Database
ISI
SICI code
0364-3190(200104)26:4<369:EOHOBC>2.0.ZU;2-C
Abstract
We evaluated the anti-inflammatory and neuroprotective effects of hypotherm ia during the early phase of experimental Escherichia coli meningitis in th e newborn piglet. Hypothermia significantly attenuated the meningitis-induc ed acute inflammatory responses such as increased intracranial pressure, de creased glucose level, increased lactate concentration, increased tumor nec rosis factor-ct. level and leukocytosis in the cerebrospinal fluid. Decreas ed cerebral cortical cell membrane Na+,K+-ATPase activity and increased lip id peroxidation products, indicative of meningitis-induced brain damage, we re significantly improved with hypothermia. Hypothermia also significantly improved the meningitis-induced reduction in brain ATP and phosphocreatine levels. In summary, hypothermia significantly attenuated the acute inflamma tory responses and the ensuing brain injury in experimental neonatal bacter ial meningitis.