Decreased activities of lipoprotein lipase and hepatic triglyceride lipasein patients with gout

Tsutsumi, Z Yamamoto, T Moriwaki, Y Takahashi, S Hada, T

Z. Tsutsumi et al., Decreased activities of lipoprotein lipase and hepatic triglyceride lipasein patients with gout, METABOLISM, 50(8), 2001, pp. 952-954

18

INGLESE

Article

Endocrinology, Nutrition & Metabolism

METABOLISM-CLINICAL AND EXPERIMENTAL

0026-0495 → ACNP

50

8

2001

952 - 954

ISI

0026-0495(200108)50:8<952:DAOLLA>2.0.ZU;2-9

Postheparin plasma lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities were measured in 30 male primary gout patients as well a s in control subjects. The activities of these lipolytic enzymes were signi ficantly decreased in the patients as compared with the controls (gout v co ntrol; LPL,5.4 +/-0.4 v 7.9 +/-0.9 U; HTGL, 14.6 +/-2.0 v 17.9 +/-3.4 U) wh en matched with serum triglyceride concentration. Further, LPL activity was negatively correlated with serum- and very-low-density lipoprotein (VLDL)- triglyceride in gout patients, while that of HTGL was negatively correlated with low-density lipoprotein (LDL)-triglyceride in both gout patients and control subjects. These results suggest that decreased activities of LPL an d HTGL may contribute, in part, to the increased concentrations of serum-, VLDL-, and LDL-triglyceride seen in gout patients, leading to a higher risk for coronary atherosclerotic diseases in gout. Copyright (C) 2001 by W.B. Saunders Company.