Decreased activities of lipoprotein lipase and hepatic triglyceride lipasein patients with gout

Citation
Z. Tsutsumi et al., Decreased activities of lipoprotein lipase and hepatic triglyceride lipasein patients with gout, METABOLISM, 50(8), 2001, pp. 952-954
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN journal
0026-0495 → ACNP
Volume
50
Issue
8
Year of publication
2001
Pages
952 - 954
Database
ISI
SICI code
0026-0495(200108)50:8<952:DAOLLA>2.0.ZU;2-9
Abstract
Postheparin plasma lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities were measured in 30 male primary gout patients as well a s in control subjects. The activities of these lipolytic enzymes were signi ficantly decreased in the patients as compared with the controls (gout v co ntrol; LPL,5.4 +/-0.4 v 7.9 +/-0.9 U; HTGL, 14.6 +/-2.0 v 17.9 +/-3.4 U) wh en matched with serum triglyceride concentration. Further, LPL activity was negatively correlated with serum- and very-low-density lipoprotein (VLDL)- triglyceride in gout patients, while that of HTGL was negatively correlated with low-density lipoprotein (LDL)-triglyceride in both gout patients and control subjects. These results suggest that decreased activities of LPL an d HTGL may contribute, in part, to the increased concentrations of serum-, VLDL-, and LDL-triglyceride seen in gout patients, leading to a higher risk for coronary atherosclerotic diseases in gout. Copyright (C) 2001 by W.B. Saunders Company.