Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis - Behcet's syndrome

Citation
S. Kimura et al., Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis - Behcet's syndrome, LEUK LYMPH, 42(1-2), 2001, pp. 115-121
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
42
Issue
1-2
Year of publication
2001
Pages
115 - 121
Database
ISI
SICI code
1042-8194(200106)42:1-2<115:T8IIMS>2.0.ZU;2-H
Abstract
Only 12 myelodysplastic syndrome (MDS) cases with Behcet's syndrome have be en previously reported and trisomy 8 was found to have accumulated in all t hese patients. Five of the cases had complications in the form of multiple intestinal ulcers, which is one of the symptoms of Behcet's syndrome. To in vestigate the relationship between trisomy 8 and multiple intestinal ulcers in NOS patients, we analyzed 46 MDS cases treated in our hospital over the last decade, and trisomy 8 was observed in eight of them. Three of these c ases had complications of both multiple intestinal ulcers and thrombosis, a nd two cases showed episodes of thrombosis without intestinal ulcers. All t hese five cases featured trisomy 8, while the other 38 MDS patients without trisomy 8 had no episode of either intestinal ulcer or thrombosis. TWO of the three cases suffering from multiple intestinal ulcers were treated with granulocyte-colony stimulating factor (G-CSF), which resulted in aggravati on of the symptoms. Although the influence of G-CSF on such symptoms in MDS patients with trisomy 8 remains unclear, it seems advisable to exercise ca ution in the use of G-CSF when an MDS patient with trisomy 8 has intestinal ulcers or thrombosis.