Suppressors of cancer cell proliferation from fig (Ficus carica) resin: Isolation and structure elucidation

Citation
S. Rubnov et al., Suppressors of cancer cell proliferation from fig (Ficus carica) resin: Isolation and structure elucidation, J NAT PROD, 64(7), 2001, pp. 993-996
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
993 - 996
Database
ISI
SICI code
0163-3864(200107)64:7<993:SOCCPF>2.0.ZU;2-T
Abstract
A mixture of 6-O-acyl-beta -D-glucosyl-beta -sitosterols, the acyl moeity b eing primarily palmitoyl and linoleyl with minor amounts of stearyl and ole yl, has been isolated as a potent cytotoxic agent from fig (Ficus carica) l atex and soybeans. Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various c ancer cell lines.