Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex

Citation
S. Boonphong et al., Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex, J NAT PROD, 64(7), 2001, pp. 965-967
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
965 - 967
Database
ISI
SICI code
0163-3864(200107)64:7<965:MAABNA>2.0.ZU;2-W
Abstract
Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were i solated from the broth extract of the fungus Xylaria multiplex BCC 1111. Ch emical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC50 values of 7 and 2 mug/mL, respectively. Both 1 a nd 2 were inactive in the screening systems toward the malarial parasite Pl asmodium falciparum (at 20 mug/mL) and were not cytotoxic to BC-1 and KB ce ll lines (at 20 mug/mL).