Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives

Authors
Ishida, J Wang, HK Oyama, M Cosentino, ML Hu, CQ Lee, KH
Citation
J. Ishida et al., Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives, J NAT PROD, 64(7), 2001, pp. 958-960
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
958 - 960
Database
ISI
SICI code
0163-3864(200107)64:7<958:AA4AAO>2.0.ZU;2-O
Abstract
Matairesinol (1) and harman (5), identified from Symplocos setchuensis, wer e found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluat ion of 28 derivatives of 5 revealed that compound 19 showed potent activity with EC50 and therapeutic index values of 0.037 muM and 210, respectively.