Antimicrobial cuparene-type sesquiterpenes, enokipodins C and D, from a mycelial culture of Flammulina velutipes

Citation
Nk. Ishikawa et al., Antimicrobial cuparene-type sesquiterpenes, enokipodins C and D, from a mycelial culture of Flammulina velutipes, J NAT PROD, 64(7), 2001, pp. 932-934
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
932 - 934
Database
ISI
SICI code
0163-3864(200107)64:7<932:ACSECA>2.0.ZU;2-Y
Abstract
Two new cuparene-type sesquiterpenes, enokipodins C (1) and D (2), were iso lated from culture medium of an edible mushroom, Flammulina velutipes, alon g with enokipodins A (3) and B (4). The structures of 1 and 2 were determin ed using spectroscopic methods (HRMS, H-1 and C-13, and 2D NMR). The absolu te configuration of enokipodin C was determined from the observed IH NMR ch emical shifts and NOEs in NOESY experiments after conversion into the corre sponding esters with the chiral reagent 2-(2'-methoxy-1'-naphthyl)-3,4-dich lorobenzoic acid. All the metabolites showed antimicrobial activity against a fungus, Cladosporium herbarum, and Gram-positive bacteria, Bacillus subt ilis and Staphylococcus aureus.