Seven new annonaceous acetogenins, muricins A-G (1-7), as well as five know
n compounds, a mixture of muricatetrocin A (8) and muricatetrocin B (9), lo
ngifolicin (10), corossolin (11), and corossolone (12), were isolated from
the seeds of Annona muricata. The structures of all isolates were elucidate
d and characterized by spectral and chemical methods. These acetogenins sho
wed significantly selective in vitro cytotoxicities toward the human hepato
ma cell lines Hep G(2) and 2,2,15.