Biological and mechanistic activities of xanthorrizol and 4-(1 ',5 '-dimethylhex-4 '-enyl)-2-methylphenol isolated from Iostephane heterophylla

Mata, R Martinez, E Bye, R Morales, G Singh, MP Janso, JE Maiese, WM Timmermann, B

R. Mata et al., Biological and mechanistic activities of xanthorrizol and 4-(1 ',5 '-dimethylhex-4 '-enyl)-2-methylphenol isolated from Iostephane heterophylla, J NAT PROD, 64(7), 2001, pp. 911-914

14

INGLESE

Article

Agricultural Chemistry","Pharmacology & Toxicology

JOURNAL OF NATURAL PRODUCTS

0163-3864 → ACNP

64

7

2001

911 - 914

ISI

0163-3864(200107)64:7<911:BAMAOX>2.0.ZU;2-K

Xanthorrizol (1) and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol (2) were identified as the principal antimicrobial components of a CH2Cl2-MeOH (1:1) extract derived from Iostephane heterophylla. Compound 2 is a new natural product, but has been synthesized. Both compounds exhibited low level activ ity (MICs of 16-32 mug/mL) against methicillin-resistant staphylococci and vancomycin-resistant enterococci. They were either inactive or poorly activ e against Gram-negative bacteria and yeast. Mechanistic studies performed i n Escherichia coli imp suggested nonspecific inhibition of DNA, RNA, and pr otein synthesis by both of these compounds. Compound I was tested in an in vivo model; it did not provide protection to mice infected with Staphylococ cus aureus.