In vitro cytotoxicity of the protoberberine-type alkaloids

Citation
K. Iwasa et al., In vitro cytotoxicity of the protoberberine-type alkaloids, J NAT PROD, 64(7), 2001, pp. 896-898
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
896 - 898
Database
ISI
SICI code
0163-3864(200107)64:7<896:IVCOTP>2.0.ZU;2-K
Abstract
In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids rel ated to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. Extending the alkyl chain at posi tion 8 or 13 strongly influenced the cytotoxic activity, that is, relative lipophilicity as well as the size of the substituent affects cytotoxicity. The highest level of activity was observed in 8- or 13-hexyl-substituted de rivatives of berberine. Structure - activity relationships are described.