Antiinflammatory constituents from Heterotheca inuloides

Citation
G. Delgado et al., Antiinflammatory constituents from Heterotheca inuloides, J NAT PROD, 64(7), 2001, pp. 861-864
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
861 - 864
Database
ISI
SICI code
0163-3864(200107)64:7<861:ACFHI>2.0.ZU;2-9
Abstract
Three new compounds, cadalen-15-oic acid (1), 3,7-dihydroxy-3(4H)-isocadale n-4-one (2), and dicadalenol (3), were isolated from the aerial parts of He terotheca inuloides (Mexican arnica), together with the known compounds 7-h ydroxycadalene (4), 7-hydroxy-4 alphaH-3,4-dihydrocadalene (5), 1 alpha -hy droxy-1(4H)-isocadalen-4-one (6), 1 alpha -hydroxy-4 alphaH-1,2,3,4-tetrahy drocadalen-15-oic acid (7), 7-(3,3-dimethylallyloxy)coumarin, caryolan-1,9 beta -diol, and quercetin. The structures of the new compounds were elucida ted by spectroscopic methods. The antiinflammatory activities of the extrac ts and the isolated compounds were evaluated by determining the inhibition of TPA-induced mouse ear edema. The natural products 3, caryolan-1,9,beta - diol, and quercetin were the most active substances tested and displayed do se-dependent activities.