gamma delta T-cell lymphoma with tropism for various types of epithelium in a cow

Citation
K. Kadota et al., gamma delta T-cell lymphoma with tropism for various types of epithelium in a cow, J COMP PATH, 124(4), 2001, pp. 308-312
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF COMPARATIVE PATHOLOGY
ISSN journal
0021-9975 → ACNP
Volume
124
Issue
4
Year of publication
2001
Pages
308 - 312
Database
ISI
SICI code
0021-9975(200105)124:4<308:GDTLWT>2.0.ZU;2-V
Abstract
A 2-year-old Holstein cow developed multiple cutaneous masses, up to 10 cm in diameter, over the neck and trunk. The animal also had neoplastic lesion s in internal Organs. and epitheliotropism was observed not only in the ski n but also in the conjunctiva, mammary glands, trachea, abomasum, small int estine, gall bladder, uterus and urinary bladder. Moreover, the neoplastic cells showed preferential homing to T-zones of lymphatic tissues. Because t he lymphoma cells were positive for CD3 but not CD79a. and a few were CD2- or WCI-positive, this lymphoma was thought to be of gamma delta T-cell orig in. Helicobacter-like organisms, found in the abomasum and small intestine, were considered to be associated with the severe neoplastic involvement of these organs, on the basis of the intense immunolabelling for major histoc ompatibility complex class II in the epithelial cells, and the presence of increased numbers of apparently normal intraepithelial T lymphocytes. (C) 2 001 Harcourt Publishers Ltd.