Burkholderia cepacia complex infection in Italian patients with cystic fibrosis: Prevalence, epidemiology, and genomovar status

Citation
A. Agodi et al., Burkholderia cepacia complex infection in Italian patients with cystic fibrosis: Prevalence, epidemiology, and genomovar status, J CLIN MICR, 39(8), 2001, pp. 2891-2896
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
0095-1137 → ACNP
Volume
39
Issue
8
Year of publication
2001
Pages
2891 - 2896
Database
ISI
SICI code
0095-1137(200108)39:8<2891:BCCIII>2.0.ZU;2-3
Abstract
The prevalence, epidemiology, and genomovar status of Burkholderia cepacia complex strains recovered from Italian cystic fibrosis (CF) patients were i nvestigated using genetic typing and species identification methods. Four C F treatment centers were examined: two in Sicily, one in central Italy, and one in northern Italy. B. cepacia complex bacteria were isolated from 59 o ut of 683 CF patients attending these centers (8.6%). For the two geographi cally related treatment centers in Sicily, there was a high incidence of in fection caused by a single epidemic clone possessing the cbLA gene and belo nging to B. cepacia genomovar III, recA group III-A, closely related to the major North America-United Kingdom clone, ET12; instability of the cblA se quence was also demonstrated for clonal isolates. In summary, of all the st rains of B. cepacia encountered in the Italian CF population, the genomovar III, recA group III-A strains were the most prevalent and transmissible. H owever, patient-to-patient spread was also observed with several other geno movars, including strains of novel taxonomic status within the B. cepacia c omplex. A combination of genetic identification and molecular typing analys is is recommended to fully define specific risks posed by the genomovar sta tus of strains within the B. cepacia complex.