Long-term outcome of systemic cyclosporine treatment following penetratingkeratoplasty

Citation
K. Inoue et al., Long-term outcome of systemic cyclosporine treatment following penetratingkeratoplasty, JPN J OPHTH, 45(4), 2001, pp. 378-382
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Optalmology
Journal title
JAPANESE JOURNAL OF OPHTHALMOLOGY
ISSN journal
0021-5155 → ACNP
Volume
45
Issue
4
Year of publication
2001
Pages
378 - 382
Database
ISI
SICI code
0021-5155(200107/08)45:4<378:LOOSCT>2.0.ZU;2-C
Abstract
Purpose: To perform a retrospective study to evaluate the long-term outcome of systemic cyclosporine treatment as an adjunct to topical corticosteroid treatment after penetrating keratoplasty (PKP). Methods: Twenty-six high-risk patients (27 eyes) who received systemic cycl osporine following PIC-P for an average of 5.4 months were compared with an other series of 57 patients (57 eyes) who did not receive cyclosporine afte r PKP. Results: Endothelial rejection developed in 2 cases during cyclosporine tre atment and in 6 cases after discontinuation. The rate of rejection-free gra ft survival was similar between the treated and the control groups. The con trol group showed a significantly higher rate of graft survival than the tr eated group. As side effects in the treatment group, transient elevation in blood urea nitrogen or creatine developed in 7 cases. Increase in glutamet e oxaloacetate transaminase (GOT) or glutamete pyrubate transaminase (GPT) developed in 4 cases. Severe side effects were absent throughout the series in both groups of patients. Conclusion: Systemic cyclosporine treatment for several months did not redu ce the. incidence of rejection nor improve the rate of graft clarity in the long term in high-risk patients after PKP. Jpn J Ophthalmol 2001;45:378-38 2 (C) 2001 Japanese Ophthalmological Society.