MICA engagement by human V gamma 2V delta 2 T cells enhances their antigen-dependent effector function

Citation
H. Das et al., MICA engagement by human V gamma 2V delta 2 T cells enhances their antigen-dependent effector function, IMMUNITY, 15(1), 2001, pp. 83-93
Citations number
53
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
IMMUNITY
ISSN journal
1074-7613 → ACNP
Volume
15
Issue
1
Year of publication
2001
Pages
83 - 93
Database
ISI
SICI code
1074-7613(200107)15:1<83:MEBHVG>2.0.ZU;2-V
Abstract
V gamma 2V delta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these V gamma 2V delta2 T cells ex pand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induced on the surface of dendritic and epithelial cell s by infection with M. tuberculosis in vitro and in vivo. MICA engagement b y the activating receptor, NKG2D. present on V gamma 2V delta2 T cells, res ulted in a substantial enhancement of the TCR-dependent V gamma 2V delta2 T cell response to nonpeptide antigens and protein superantigens alike. Thus , a MICA-NKG2D interaction may be necessary for an effective innate immune response to microbe-associated antigens that also are constitutively presen t in vivo.