Background/Aims: Recently, it has been proposed that decreased intestinal m
otility in fasting-induced hyperbifirubinemic rats probably results in an i
ncrease in the enterohepatic cycling of unconjugated bilirubin. We investig
ated the association among gastric emptying, intestinal transit time, and s
erum unconjugated levels in subjects with Gilbert's syndrome.
Methodology: Ten subjects with Gilbert's syndrome were included in this stu
dy according to the following criteria: fasting hyperbilirubinemia; no hemo
lysis or gastrointestinal disorders and free of any medication. Five normal
, healthy volunteers acted as controls. Gastric emptying and intestinal tra
nsit time were evaluated after overnight fasting by administration of a sta
ndard meal mixed with 1-2ci of Tc-99-labeled diethylene-triamine-pentacetic
acid. Serum unconjugated bilirubin levels were determined by high-performa
nce liquid chromatography.
Results: The gastric emptying in Gilbert's syndrome subjects was 134.1 +/-
38.9 and 90.9 +/-6.5min in controls, P <0.03. It was a tendency to have a s
horter intestinal transit time in subjects with Gilbert's syndrome, 138.3 /- 59.0, than in control subjects, 183.8 +/- 11.3min. Serum unconjugated bi
lirubin levels (mg/dL) were 2.6 +/-1.04 and 0.95 +/-0.34, P <0.01.
Conclusions: Gastric emptying is delayed significantly in Gilbert's syndrom
e, and intestinal transit time differences between Gilbert's syndrome subje
cts and controls were not significantly different.