Delayed gastric emptying in subjects with Gilbert's syndrome

Citation
N. Mendez-sanchez et al., Delayed gastric emptying in subjects with Gilbert's syndrome, HEP-GASTRO, 48(40), 2001, pp. 1183-1185
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
HEPATO-GASTROENTEROLOGY
ISSN journal
0172-6390 → ACNP
Volume
48
Issue
40
Year of publication
2001
Pages
1183 - 1185
Database
ISI
SICI code
0172-6390(200107/08)48:40<1183:DGEISW>2.0.ZU;2-5
Abstract
Background/Aims: Recently, it has been proposed that decreased intestinal m otility in fasting-induced hyperbifirubinemic rats probably results in an i ncrease in the enterohepatic cycling of unconjugated bilirubin. We investig ated the association among gastric emptying, intestinal transit time, and s erum unconjugated levels in subjects with Gilbert's syndrome. Methodology: Ten subjects with Gilbert's syndrome were included in this stu dy according to the following criteria: fasting hyperbilirubinemia; no hemo lysis or gastrointestinal disorders and free of any medication. Five normal , healthy volunteers acted as controls. Gastric emptying and intestinal tra nsit time were evaluated after overnight fasting by administration of a sta ndard meal mixed with 1-2ci of Tc-99-labeled diethylene-triamine-pentacetic acid. Serum unconjugated bilirubin levels were determined by high-performa nce liquid chromatography. Results: The gastric emptying in Gilbert's syndrome subjects was 134.1 +/- 38.9 and 90.9 +/-6.5min in controls, P <0.03. It was a tendency to have a s horter intestinal transit time in subjects with Gilbert's syndrome, 138.3 /- 59.0, than in control subjects, 183.8 +/- 11.3min. Serum unconjugated bi lirubin levels (mg/dL) were 2.6 +/-1.04 and 0.95 +/-0.34, P <0.01. Conclusions: Gastric emptying is delayed significantly in Gilbert's syndrom e, and intestinal transit time differences between Gilbert's syndrome subje cts and controls were not significantly different.