Differential expression analysis of matrix metalloproteinase 20 (MMP20) inhuman esophageal cancer

Citation
Ch. Yang et al., Differential expression analysis of matrix metalloproteinase 20 (MMP20) inhuman esophageal cancer, CHIN SCI B, 46(12), 2001, pp. 1009-1012
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
1001-6538 → ACNP
Volume
46
Issue
12
Year of publication
2001
Pages
1009 - 1012
Database
ISI
SICI code
1001-6538(200106)46:12<1009:DEAOMM>2.0.ZU;2-U
Abstract
The aim of this study was to investigate the different expressions of MMP20 in the process of esophageal cancer. RT-PCR, immunohistochemistry and West ern blot were employed to detect the mRNA expression and protein expression of MMP20. Compared with the corresponding normal esophagus tissues, result s showed the common trend of the dramatical overexpression of MMP20 in the esophageal cancer tissues. The analysis of MMP20 expression in different cl inical early stages of esophageal cancer by RT-PCR indicated that MMP20 was much more overexpressed in the esophageal cancer with invasion than in the early stages. This suggested that MMP20 might play an important role in th e progression of esophageal cancer. It probably plays a critical role in tu mor invasion.