Increased plasma concentration of adrenomedullin during and after major surgery

Authors
Citation
S. Fujioka, Increased plasma concentration of adrenomedullin during and after major surgery, SURG TODAY, 31(7), 2001, pp. 575-579
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
SURGERY TODAY
ISSN journal
0941-1291 → ACNP
Volume
31
Issue
7
Year of publication
2001
Pages
575 - 579
Database
ISI
SICI code
0941-1291(2001)31:7<575:IPCOAD>2.0.ZU;2-F
Abstract
Adrenomedullin (AM), a novel vasodilatory peptide, appears to participate i n the regulation of circulation. Recent studies have reported a relationshi p between AM and cytokine. The present study was performed to determine whe ther major surgery, which is accompanied by an altered cytokine production, affects the concentration of plasma AM. Eighteen patients undergoing major upper abdominal and thoracoabdominal surgery were thus studied. Arterial b lood samples were obtained before anesthetic induction (PRE), 2h after a su rgical incision was made (2H), at the end of surgery (END), at postoperativ e day 1 (1POD), and at 3POD. The concentrations of plasma AM and serum inte rleukin (IL)-6 were measured. The levels of plasma AM were found to be sign ificantly higher at END (P < 0.001), 1POD (P < 0.0001), and 3POD (P < 0.05) compared with PRE. A significant correlation was found between the concent rations of serum IL-6 and plasma AM (r = 0.59, n = 18, P < 0.01). These res ults suggest that major surgical stress might thus increase the plasma AM c oncentration, and such an increase may be related to cytokine induction.