Improvements in cardiovascular risk profile with large-volume liposuction:A pilot study

Citation
Sy. Giese et al., Improvements in cardiovascular risk profile with large-volume liposuction:A pilot study, PLAS R SURG, 108(2), 2001, pp. 510-519
Citations number
55
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
PLASTIC AND RECONSTRUCTIVE SURGERY
ISSN journal
0032-1052 → ACNP
Volume
108
Issue
2
Year of publication
2001
Pages
510 - 519
Database
ISI
SICI code
0032-1052(200108)108:2<510:IICRPW>2.0.ZU;2-K
Abstract
In this study, the authors investigated the physiologic effects of the alte red body composition that results from surgical removal of large amounts of subcutaneous adipose tissue. Fourteen women with body mass indexes of grea ter than > 27 kg/m(2) underwent measurements of fasting plasma insulin, tri glycerides, cholesterol, body composition by dual-energy x-ray absorptiomet ry (DXA), resting energy expenditure, and blood pressure before and after u ndergoing large-volume ultrasound-assisted liposuction. There were no significant intraoperative complications. Body weight had dec reased by 5.1 kg (p < 0.0001) by 6 weeks after liposuction, with an additio nal 1.3-kg weight loss (p < 0.05) observed between 6 weeks and 4 months aft er surgery, for a total weight loss of 6.5 kg (p < 0.00006). Body mass inde x decreased from (mean +/- SEM) 28.8 +/- 2.3 to 26.8 +/- 1.5 kg/m(2) (p < 0 .0001). This change in body weight was primarily the result of decreases in body fat mass: as assessed by DXA, lean body mass did not change (43.8 +/- 3.1 kg to 43.4 +/- 3.6 kg, p = 0.80.), whereas DXA total body fat mass dec reased from 35.7 +/- 6.3 to 30.1 +/- 6.5 kg (P < 0.0001). There were signif icant decreases in fasting plasma insulin levels (14.9 +/- 6.5 mIU/ml befor e liposuction versus 7.2 +/- 3.2 mIU/ml 4 months after liposuction, P < 0.0 07), and systolic blood pressure (132.1 +/- 7.2 versus 120.5 +/- 7.8 mmHg, p < 0.0002). Total cholesterol, high-density lipoprotein cholesterol, plasm a triglycerides, and resting energy expenditure values were not significant ly altered after liposuction. In conclusion, over a 4-month period, large-volume liposuction decreased we ight, body fat mass, systolic blood detrimental effects on sure, and fastin g insulin levels without det lean body mass, bone mass, resting energy expe nditure, or lipid profiles. Should these improvements be maintained over ti me, liposuction may prove to be a valuable tool for reducing the comorbid c onditions associated with obesity.