The cytosolic HinT protein of Mycoplasma hominis interacts with two membrane proteins

Citation
A. Kitzerow et B. Henrich, The cytosolic HinT protein of Mycoplasma hominis interacts with two membrane proteins, MOL MICROB, 41(1), 2001, pp. 279-287
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
MOLECULAR MICROBIOLOGY
ISSN journal
0950-382X → ACNP
Volume
41
Issue
1
Year of publication
2001
Pages
279 - 287
Database
ISI
SICI code
0950-382X(200107)41:1<279:TCHPOM>2.0.ZU;2-S
Abstract
Histidine triad nucleotide-binding (HinT) proteins are dimeric proteins tha t bind to purines and are found in all three kingdoms: the eukarya, bacteri a and archaea. In eukaryotes, HinT proteins have been detected intracellula rly, but their function is unknown. Until now, knowledge about HinT protein s in prokaryotes was restricted to sequence similarities and nucleotide-bin ding studies. In this study, we provide evidence that, in the cell wall-les s prokaryote, Mycoplasma hominis, the gene encoding the HinT protein forms an operon with two other genes, These genes encode the species-specific mem brane proteins, P60 and P80, which are associated within the mycoplasma mem brane. The finding that HinT interacts with this complex by binding to pan provides novel insight into the organization of bacterial HinT proteins.