Genetic analysis of a local recurrent tumor after colonic polypectomy

Citation
M. Takada et al., Genetic analysis of a local recurrent tumor after colonic polypectomy, J GASTRO, 36(7), 2001, pp. 500-503
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF GASTROENTEROLOGY
ISSN journal
0944-1174 → ACNP
Volume
36
Issue
7
Year of publication
2001
Pages
500 - 503
Database
ISI
SICI code
0944-1174(200107)36:7<500:GAOALR>2.0.ZU;2-Y
Abstract
After polypectomy, the cut end of the polyp is usually examined by light mi croscopy to assess the risk of recurrent cancer. Here, we report a recurren t tumor that appeared in the colon 6 years after polypectomy, although canc er cells were not observed in hematoxylin and eosin-stained sections of the cut end of the primary polyp. Retrospectively, the primary polyp and the r ecurrent tumor were analyzed for mutations of the p53 gene. We detected p53 mutations in the primary polyp, even in the cut end of the polyp. The same set of two p53 mutations was detected in the recurrent tumor. These observ ations indicate a common origin of the primary tumor and the recurrent tumo r. We conclude that it is important to analyze p53 mutations in colonic pol yps, especially when the cut end of the polyp is difficult to evaluate hist ologically, in order to predict recurrence.