A second primary esophageal cancer developing 7 years after chemoradiotherapy for advanced esophageal cancer

Citation
R. Suto et al., A second primary esophageal cancer developing 7 years after chemoradiotherapy for advanced esophageal cancer, J GASTRO, 36(7), 2001, pp. 495-499
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF GASTROENTEROLOGY
ISSN journal
0944-1174 → ACNP
Volume
36
Issue
7
Year of publication
2001
Pages
495 - 499
Database
ISI
SICI code
0944-1174(200107)36:7<495:ASPECD>2.0.ZU;2-U
Abstract
We report a rare case of advanced carcinoma and a second primary carcinoma of the esophagus, both of which were successfully cured by chemotherapy and operation at different times. In 1991, a 38-year-old Japanese man was diag nosed with advanced esophageal cancer, which was unresectable because of th e bronchial invasion of the tumor. He was given chemotherapy with cisplatin (CDDP), combined with radiotherapy. During a 4-year follow-up, neither reg rowth of the primary tumor nor distant metastasis occurred. In 1995, esopha goscopy demonstrated a lugol-unstained region located 3cm distal from the a rea of radiation to the primary lesion shown by esophagography. Histologica l examination of a biopsy specimen showed the mucosa to be normal. Neverthe less, yearly surveillance by endoscopy and histological examinations showed that the mucosa of the esophagus gradually began to demonstrate mild dyspl asia, followed by severe dysplasia; in 1998, a diagnosis of squamous cell c arcinoma was made. Esophagectomy with lymph node dissection was performed. Microscopic examination revealed that there had been pathologic complete re sponse for the original advanced esophageal cancer.