BODY-WEIGHT AND RISK OF NONFATAL ACUTE MYOCARDIAL-INFARCTION AMONG WOMEN - A CASE-CONTROL STUDY FROM NORTHERN ITALY

Citation
A. Tavani et al., BODY-WEIGHT AND RISK OF NONFATAL ACUTE MYOCARDIAL-INFARCTION AMONG WOMEN - A CASE-CONTROL STUDY FROM NORTHERN ITALY, Preventive medicine, 26(4), 1997, pp. 550-555
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public, Environmental & Occupation Heath","Medicine, General & Internal
Journal title
ISSN journal
0091-7435
Volume
26
Issue
4
Year of publication
1997
Pages
550 - 555
Database
ISI
SICI code
0091-7435(1997)26:4<550:BARONA>2.0.ZU;2-N
Abstract
Background. The relationship between nonfatal acute myocardial infarct ion (AMI) and self-reported body weight and body mass index (EMI; Quet elet index, kg/m(2)) has been investigated. Methods. A case-control st udy was conducted between 1983 and 1992 in northern Italy on 432 women with nonfatal AMI and 867 controls in hospital for acute, noncardiova scular, nonneoplastic, nondigestive, non-hormone-related conditions. O dds ratios (OR), with their 95% confidence intervals (CI), were comput ed by unconditional multiple logistic regression analysis, including t erms for age, education, and smoking, plus history of selected disease s. Results. Women with body weight and BMI in the highest quartile had an increased risk of AMI after allowance for age, education, and smok ing status (OR 1.5, 95% CI 1.0 to 2.2, and OR 1.7, 95% CI 1.2 to 2.4, respectively). Compared with leaner women, the risk was higher among w omen with BMI above the median, in association with a history of diabe tes (OR 5.2) or hyperlipidemia (OR 6.0). Hypertensive women had simila r OR in the two strata of BMI (OR 5.1 and 4.8). The association of EMI with risk of AMI was apparently stronger among women younger than 50 years and among less educated women, but was similar among smokers and never smokers. Conclusions. The results of this study confirm that AM I among women is related to excess BMI, with a population attributable risk of 17%. The excess risk was substantial among overweight women w ith history of diabetes or hyperlipidemia, stressing the importance of controlling body weight among these women. (C) 1997 Academic Press.