Gender difference in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension

Citation
H. Takizawa et al., Gender difference in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension, CLIN EXP HY, 23(4), 2001, pp. 357-368
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
CLINICAL AND EXPERIMENTAL HYPERTENSION
ISSN journal
1064-1963 → ACNP
Volume
23
Issue
4
Year of publication
2001
Pages
357 - 368
Database
ISI
SICI code
1064-1963(200105)23:4<357:GDITRA>2.0.ZU;2-Y
Abstract
Studies reveals that plasma leptin levels (LEP) in females are higher than those in males, and that LEP in hypertensive subjects are higher than those in BMI-matched normotensive subjects. To investigate the relationships amo ng LEP, blood pressure (BP) and insulin sensitivity, we studied these relat ionships in 133 Japanese males and 263 females. LEP were positively correla ted with BP, body mass index, body fat mass (FM) and homeostasis model asse ssment (HOMA). Regression analysis in which age and FM were adjusted showed LEP were associated with BP and HOMA. Even with adjustment by age, FM and HOMA, LEP were still positively correlated BP in males. LEP in insulin-resi stant hypertensives was significantly higher than those in insulin-sensitiv e hypertensives, in insulin-sensitive normotensives and in insulin-resistan t normotensives in males. However, in females, a significantly higher LEP w as observed in insulin-resistant subjects than in insulin-sensitive subject s regardless of hypertension. These data suggest that it would be sexual di fference in the relationships among hyperleptinemia. hyperinsulinemia and h ypertension.