Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity

Citation
M. Kuroda et al., Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity, CHEM PHARM, 49(8), 2001, pp. 1042-1046
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0009-2363 → ACNP
Volume
49
Issue
8
Year of publication
2001
Pages
1042 - 1046
Database
ISI
SICI code
0009-2363(200108)49:8<1042:CGFTBO>2.0.ZU;2-T
Abstract
Further search for cytotoxic compounds contained in the bulbs of Galtonia c andicans (Liliaceac) led to the isolation of four potent cytotoxic cholesta ne glycosides (1-4) based upon 3 beta ,16 beta ,17 alpha -trihydroxycholest -5-en-22-one, three of which (2-4) have not been reported previously. A new cholestane bisdesmoside (5) and a now rearranged cholestane glycoside (6) were also isolated. The structural assignment of the new constituents as ca rried out by spectroscopic analysis and a few chemical transformations.