ACE inhibitors versus AT(1) blockers in the treatment of hypertension and syndrome X

Authors
Citation
R. Feldman, ACE inhibitors versus AT(1) blockers in the treatment of hypertension and syndrome X, CAN J CARD, 16, 2000, pp. 41-44
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
CANADIAN JOURNAL OF CARDIOLOGY
ISSN journal
0828-282X → ACNP
Volume
16
Year of publication
2000
Supplement
E
Pages
41 - 44
Database
ISI
SICI code
0828-282X(200008)16:<41:AIVABI>2.0.ZU;2-I
Abstract
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 (A TI) receptor blockers are two separate classes of drugs. Although they are both effective antihypertensive agents, they exert their effects through di fferent pharmacological mechanisms. Nonetheless, they have often proved ind istinguishable in terms of the surrogate endpoints used in short term clini cal studies. Considerable data are available on the long term benefits of A CE inhibition; however, studies looking at the long term effects of AT(1) r eceptor blockade are not yet complete. If ACE inhibitors prove to be distin guishable from AT1 receptor blockers in terms of disease related outcomes, the reason may be the selective effects of ACE inhibitors on insulin resist ance and insulin-mediated vascular function.