Although the exact causative phenomenon responsible for the onset and progr
ession of neurodegenerative disorders is at present unresolved, there are s
ome clues as to the mechanisms underlying these chronic diseases. This revi
ew addresses mechanisms by which endogenous or environmental factors, throu
gh interaction with redox active metals, may initiate a common cascade of e
vents terminating in neurodegeneration. (C) 2001 Elsevier Science Inc.