Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers

Citation
Y. Omoto et al., Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers, BIOC BIOP R, 285(2), 2001, pp. 340-347
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006-291X → ACNP
Volume
285
Issue
2
Year of publication
2001
Pages
340 - 347
Database
ISI
SICI code
0006-291X(20010713)285:2<340:EFACIO>2.0.ZU;2-2
Abstract
The higher frequency of human lung adenocarcinoma in females than in males, strongly suggests the involvement of gender dependent factors in the etiol ogy of this disease. This is the first investigation of estrogen receptor ( ER) beta in human lung. Immunohistochemical staining revealed ERP expressio n in normal lung and in atypical adenomatous hyperplasia (AAH), considered as a precancerous lesion for adenocarcinomas, Adenocarcinomas showed signif icantly higher expression of ERP than squamous cell carcinomas. On the cont rary, ER alpha expression was not detected in all cases. The functional int egrity of ERP such as the binding ability to estrogen responsive element (E RE) and transcriptional activity was confirmed using a human lung cancer ce ll line, RERF-LC-OK. Colony formation of this cell was significantly reduce d in the presence of pure antiestrogen. We conclude that ERP, but not ER al pha, is present in lung tissues with an important physiological function in normal lung. Furthermore, ERP may play a role in growth and development of adenocarcinomas, (C) 2001 Academic Press.