Combined modality treatment for locally advanced squamous-cell carcinoma of the oropharynx in a woman with Bloom's syndrome: A case report and reviewof the literature

Citation
B. Ma et al., Combined modality treatment for locally advanced squamous-cell carcinoma of the oropharynx in a woman with Bloom's syndrome: A case report and reviewof the literature, ANN ONCOL, 12(7), 2001, pp. 1015-1017
Citations number
17
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
ANNALS OF ONCOLOGY
ISSN journal
0923-7534 → ACNP
Volume
12
Issue
7
Year of publication
2001
Pages
1015 - 1017
Database
ISI
SICI code
0923-7534(200107)12:7<1015:CMTFLA>2.0.ZU;2-B
Abstract
We describe a case of locally advanced unresectable squamous-cell carcinoma of the oropharynx in a young woman with Bloom's syndrome. She was treated with radical radiation therapy and concurrent chemotherapy (cisplatin and 5 -flurouracil). She was unable to complete treatment due to the development of severe side effects: confluent mucositis, moist desquamating skin reacti on, severe diarrhea and severe myelosupression with neutropenic sepsis. The limited relevant literature is presented. We conclude that chemotherapy sh ould be used with extreme caution in Bloom's syndrome patients.