S. Shibata et Y. Yamashita, An ultrastructural study of osteoclasts and chondroclasts in poorly calcified mandible induced by high doses of strontium diet to fetal mice, ANN ANATOMY, 183(4), 2001, pp. 357-361
A high dose strontium diet was fed to fetal mice from day 1 of gestation to
birth in order to investigate the ultrastructural changes of osteoclasts/c
hondroclasts when associated with poorly calcified bone/cartilage. Calcific
ation in the mandibular bone and condylar cartilage was extensively inhibit
ed by this diet. Multinucleated osteoclasts and chondroclasts were observed
on the mandibular alveolar bone and in the resorption area of the condylar
cartilage, respectively. However, both cell types never formed ruffled bor
ders and clear zones at the cell surfaces facing the matrices indicative of
bone resorption, although they had well-developed organelles and vacuoles.
Furthermore, they revealed signs of phagocytosis of the matrix vesicles. T
hese results indicate that osteoclasts/chondroclasts can exhibit phagocytot
ic activity in response to requirements.