An ultrastructural study of osteoclasts and chondroclasts in poorly calcified mandible induced by high doses of strontium diet to fetal mice

Citation
S. Shibata et Y. Yamashita, An ultrastructural study of osteoclasts and chondroclasts in poorly calcified mandible induced by high doses of strontium diet to fetal mice, ANN ANATOMY, 183(4), 2001, pp. 357-361
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
ISSN journal
0940-9602 → ACNP
Volume
183
Issue
4
Year of publication
2001
Pages
357 - 361
Database
ISI
SICI code
0940-9602(200107)183:4<357:AUSOOA>2.0.ZU;2-L
Abstract
A high dose strontium diet was fed to fetal mice from day 1 of gestation to birth in order to investigate the ultrastructural changes of osteoclasts/c hondroclasts when associated with poorly calcified bone/cartilage. Calcific ation in the mandibular bone and condylar cartilage was extensively inhibit ed by this diet. Multinucleated osteoclasts and chondroclasts were observed on the mandibular alveolar bone and in the resorption area of the condylar cartilage, respectively. However, both cell types never formed ruffled bor ders and clear zones at the cell surfaces facing the matrices indicative of bone resorption, although they had well-developed organelles and vacuoles. Furthermore, they revealed signs of phagocytosis of the matrix vesicles. T hese results indicate that osteoclasts/chondroclasts can exhibit phagocytot ic activity in response to requirements.