The development of synaptophysin immunoreactivity in the human sympatheticganglia

Citation
V. Roudenok et W. Kuhnel, The development of synaptophysin immunoreactivity in the human sympatheticganglia, ANN ANATOMY, 183(4), 2001, pp. 345-351
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
ISSN journal
0940-9602 → ACNP
Volume
183
Issue
4
Year of publication
2001
Pages
345 - 351
Database
ISI
SICI code
0940-9602(200107)183:4<345:TDOSII>2.0.ZU;2-W
Abstract
Using an indirect immunohistochemical method, synaptophysin immunoreactivit y (SYN-IR) has been studied in cryostat sections of stellate and thoracic g anglia in human fetuses, neonates, infants and adults. In the course of dev elopment, a progressive increase in SYN-IR in axonal terminals and around n erve cells was demonstrated. In contrast, large clusters of small intensely fluorescent (SIF) cells and paraganglionic cells increased in number in fe tuses and premature neonates at 24-25 weeks. Such SIF cell clusters varied in form and often occurred at pole or subcapsular areas of sympathetic gang lia close to blood vessels or paraganglia. With increasing gestational age and during infancy, a decrease in sizes of SIF cell groups and paraganglion ic cells as well as changes in their distribution were found. The results s how that the amount and distribution of SYN-IR is temporally related to the maturation and functional activity of human sympathetic ganglia neurons. I t was suggested that numerous SIF cells and paraganglia in human prenatal s ympathetic ganglia were both indicative of incomplete cell migration and an important source of regulation of ganglionic microcirculation under the co nditions of relative hypoxia and immature nervous regulation.