Background: Duodenogastric reflux has been implicated in the pathogenesis o
f gastric ulcer and gastritis. Duodenogastric reflux after cholecystectomy
is also a possible cause of post-cholecystectomy syndrome.
Aim: To investigate the role of antroduodenal motor function in increased d
uodenogastric reflux following cholecystectomy and the effect of trimebutin
e maleate (trimebutine) on the duodenogastric reflux in conscious dogs.
Methods: Antropyloric and duodenal motility and bile acids content in the g
astric juice were measured for 3 h during the inter-digestive state in dogs
with or without cholecystectomy.
Results: Bile acids content in the gastric juice of cholecystectomized dogs
was significantly higher than that of non-cholecystectomized dogs. The fre
quency of pyloric relaxation during phase II of the migrating motor complex
was significantly increased following cholecystectomy. Intravenous infusio
n of trimebutine inhibited both the increased duodenogastric reflux and the
frequency of pyloric relaxation in the cholecystectomized dog.
Conclusion: Duodenogastric reflux and frequency of pyloric relaxations were
increased in cholecystectomized dogs and trimebutine suppressed both of th
em. These findings suggest that the increased frequency of pyloric relaxati
on contributes to the duodenogastric reflux following cholecystectomy.