Human mast cells and basophils in HIV-1 infection

Citation
G. Marone et al., Human mast cells and basophils in HIV-1 infection, TRENDS IMMU, 22(5), 2001, pp. 229-232
Citations number
29
Language
INGLESE
art.tipo
Editorial Material
Categorie Soggetti
Immunology
Journal title
TRENDS IN IMMUNOLOGY
ISSN journal
1471-4906 → ACNP
Volume
22
Issue
5
Year of publication
2001
Pages
229 - 232
Database
ISI
SICI code
1471-4906(200105)22:5<229:HMCABI>2.0.ZU;2-Y
Abstract
Mast cells and basophils (Fc epsilon RI+ cells) are classically involved in allergic disorders. HIV-1 glycoprotein gp120 acts as a viral superantigen by interacting with the heavy chain, variable 3 (V(H)3) region of IgE to in duce cytokine release from Fc epsilon RI+ cells. The chemokine receptors CC R3 and CXCR4, co-receptors for HIV-1, a re expressed by Fc epsilon RI+ cell s, Via its interaction with CCR3, HIV-1 transactivation (Tat) protein is a potent chemoattractant for Fc epsilon RI+ cells. Incubation of basophils wi th Tat protein upregulates the surface expression of the CCR3 receptor. The re is some evidence that human Fc epsilon RI+ cells could be infected in vi tro by M-tropic HIV-1 strains.