PURPOSE: Results with different doses of gadobenate dimeglumine and gadopen
tetate dimeglumine were compared at magnetic resonance (MR) angiography of
the renal arteries. The signal-to-noise ratio (SNR) was evaluated as a quan
titative measure of image quality.
MATERIALS AND METHODS: Sixty consecutive patients (age range, 24-81 years;
mean age, 65 years) underwent intraarterial digital subtraction angiography
(DSA) and contrast material-enhanced time-resolved MR angiography. DSA was
the standard of reference. Fifteen patients received gadopentetate dimeglu
mine at doses of 0.2 or 0.1 mmol per kilogram of body weight. Fifteen patie
nts received gadobenate dimeglumine at doses of 0.05 or 0.1 mmol/kg. The SN
R was calculated in the aorta and both main renal arteries. The number and
degree of stenoses of the renal arteries and accessory vessels were evaluat
ed by four observers.
RESULTS: SNRs with gadobenate dimeglumine at a dose of 0.1 mmol/kg were sig
nificantly superior to those with gadopentetate dimeglumine at a dose of 0.
1 mmol/kg. Differences were not statistically significant between the SN Rs
in the other groups. Eleven (85%) of 13 hemodynamically significant renal
artery stenoses were detected correctly with MR angiography as were 22 (85%
) of 26 accessory renal arteries.
CONCLUSION: SNRs with gadobenate dimeglumine were higher than those with ga
dopentetate dimeglumine, but in most cases the differences in SNRs were not