Regulation of steroidogenesis in transgenic mice and zebrafish

Citation
Mc. Hu et al., Regulation of steroidogenesis in transgenic mice and zebrafish, MOL C ENDOC, 171(1-2), 2001, pp. 9-14
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
MOLECULAR AND CELLULAR ENDOCRINOLOGY
ISSN journal
0303-7207 → ACNP
Volume
171
Issue
1-2
Year of publication
2001
Pages
9 - 14
Database
ISI
SICI code
0303-7207(20010122)171:1-2<9:ROSITM>2.0.ZU;2-#
Abstract
Steroid hormones are important physiological regulators in the body. Steroi d hormones are mainly synthesized in the adrenal and gonads. Their synthesi s is stimulated by pituitary hormones through cAMP as an intracellular medi ator. The first and rate-limiting step for steroid biosynthesis is catalyze d by CYP11A1. Important regulatory elements for the control of the CYP11A1 gene expression have been characterized both in vitro and in vivo. The SF-1 -binding sites are cis-acting elements controlling the basal and cAMP-stimu lated gent expression. Our transgenic mouse studies showed that the 2.3 kb promoter contains information controlling developmentally regulated gene ex pression. Finally. we present our results on the cloning of steroidogenic g ents in zebrafish. a new model organism for genetic studies. (C) 2001 Elsev ier Science ireland Ltd. All rights reserved.