Relationship between acute morphine and the course of PTSD in children with burns

Citation
G. Saxe et al., Relationship between acute morphine and the course of PTSD in children with burns, J AM A CHIL, 40(8), 2001, pp. 915-921
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry
Journal title
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
ISSN journal
0890-8567 → ACNP
Volume
40
Issue
8
Year of publication
2001
Pages
915 - 921
Database
ISI
SICI code
0890-8567(200108)40:8<915:RBAMAT>2.0.ZU;2-C
Abstract
Objective: To investigate the relationship between the dose of morphine adm inistered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period f ollowing discharge from the hospital. Method: Twenty-four children admitted to the hospital for an acute burn were assessed twice with the Child PTSD Reaction Index: while in the hospital and 6 months after discharge. The Col ored Analogue Pain Scale was also administered during the hospitalization. All patients received morphine while in the hospital. The mean dose of morp hine (mg/kg/day) was calculated for each subject through chart review. Resu lts: The Pearson product moment correlation revealed a significant associat ion between the dose of morphine received while in the hospital and a 8-mon th reduction in PTSD symptoms. Children receiving higher doses of morphine had a greater reduction in PTSD symptoms over 6 months. Conclusions: This s tudy suggests the possibility that acute treatment with morphine can second arily prevent PTSD. This result is discussed in terms of the possible effec t of morphine on fear conditioning and the consolidation of traumatic memor y.