Determination of carbetamide in water by micro liquid-liquid extraction followed by HPLC

Citation
Mg. Munoz-soto et al., Determination of carbetamide in water by micro liquid-liquid extraction followed by HPLC, J LIQ CHR R, 24(3), 2001, pp. 355-366
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN journal
1082-6076 → ACNP
Volume
24
Issue
3
Year of publication
2001
Pages
355 - 366
Database
ISI
SICI code
1082-6076(2001)24:3<355:DOCIWB>2.0.ZU;2-7
Abstract
The validation of analytical procedures using added samples as reference ma terials is proposed. The carbetamide extracted with dichloromethane is moni tored by reverse-phase high performance liquid chromatography with a retent ion time of some 2.7 min. while Carbaryl is used as an internal standard. T he accuracy of the method is checked analysing water samples previously spi ked with different amounts of analyte. A method to obtain the signal associ ated to a chromatographic blank is presented, to include as another precaut ion, within the calibration procedures. The method was applied to the deter mination of carbetamide at very low concentration levels (2.50-10.0 mug . L -1) in different types of natural water samples. The detection limit (DL) w as 0.02 mug . L-1. Around 100% recovery levels were customarily obtained in all cases.