The chromatographic behavior of neutral molecules in Ion Interaction Chroma
tography (IIC) was theoretically investigated. The use of a potential appro
ximation to obtain a simplified retention equation was successfully tested.
The most reliable experimental literature results, concerning the retentio
n behavior of neutral molecules in IIC, were successfully fitted by the ret
The wide variability among them was elucidated on the basis of the develope
d retention equation. A new separation strategy, to improve the selectivity
of the chromatographic method, for difficult to separate mixtures of neutr
al eluates was proposed.