Analysis of pharmaceutical residues in bovine liver by HPLC

Citation
Mc. Quintana et al., Analysis of pharmaceutical residues in bovine liver by HPLC, J LIQ CHR R, 24(5), 2001, pp. 735-745
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN journal
1082-6076 → ACNP
Volume
24
Issue
5
Year of publication
2001
Pages
735 - 745
Database
ISI
SICI code
1082-6076(2001)24:5<735:AOPRIB>2.0.ZU;2-L
Abstract
A reversed-phase high performance liquid chromatographic method has been de veloped for the simultaneous analysis of a group of pharmaceuticals includi ng corticoids (dexamethasone and betamethasone acetate) and major tranquill izers (chlorpromazine, acetopromazine, propionyl promazine, xylazine, and h aloperidol) in bovine livers using U.V detection. Next to a fractionated li quid-liquid extraction, the total separation was carried out using a Kromas il C-18 column and a mixture of methanol:water (80:20, v/v) as mobile phase . All the compounds were detected at 240 nm. The detection limits ranged fr om 21 ng.mL(-1) to 298 ng.mL(-1).