Radiation therapy for superficial esophageal cancer: A comparison of radiotherapy methods

Citation
K. Nemoto et al., Radiation therapy for superficial esophageal cancer: A comparison of radiotherapy methods, INT J RAD O, 50(3), 2001, pp. 639-644
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
ISSN journal
0360-3016 → ACNP
Volume
50
Issue
3
Year of publication
2001
Pages
639 - 644
Database
ISI
SICI code
0360-3016(20010701)50:3<639:RTFSEC>2.0.ZU;2-V
Abstract
Purpose: A comparison of treatment outcomes in response to various methods of radiotherapy for superficial esophageal cancer (SEC) was carried out for a large series of patients. Methods and Materials: During the period from March 1987 to November 1998, 147 patients with superficial esophageal cancer received definitive radiati on therapy at nine radiotherapy institutions in Japan. Fifty-five patients were treated with external radiation therapy alone, 69 with high-dose-rate intracavitary radiation therapy with or without external radiation therapy, and 23 with low-dose-rate intracavitary radiation therapy and external rad iation therapy. Results: The 5-year survival rates for mucosal and submucosal cancer patien ts were 62% and 42%, respectively. The 5-year cause-specific survival rates for mucosal and submucosal cancer patients were 81% and 64%, respectively (p = 0.013), There was no statistically significant difference in the survi val rates for either mucosal or submucosal cancer patients between treatmen t groups. Metastasis was observed only in submucosal cancer patients, Esoph ageal ulcers developed only in patients who received intracavitary radiatio n therapy, and were especially common in patients treated with a fraction s ize of 5 Gy or more. Conclusions: The use of intracavitary radiation therapy does not influence the survival or local control rate of SEC, Optimal radiotherapy methods for SEC should be determined by a randomized clinical trial. (C) 2001 Elsevier Science Inc.