Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs

Citation
Xl. Jin et al., Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs, DIG DIS SCI, 46(6), 2001, pp. 1171-1176
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
DIGESTIVE DISEASES AND SCIENCES
ISSN journal
0163-2116 → ACNP
Volume
46
Issue
6
Year of publication
2001
Pages
1171 - 1176
Database
ISI
SICI code
0163-2116(200106)46:6<1171:IAIAOT>2.0.ZU;2-R
Abstract
The aim of the present study was to study the effect and mechanism of actio n of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clini cally effective for uncomplicated postoperative adhesive intestinal obstruc tion, on upper gastrointestinal motility. Five mongrel dogs were equipped w ith four strain-gauge force transducers on the antrum, duodenum, and proxim al and distal jejunum to measure contractile activity. Dai-kenchu-to (0.5, 1.5, and 3.0 g) was administered into the duodenal or proximal jejunal lume n. The effect of atropine, hexamethonium, phentolamine, propranolol, and on dansetron on intraduodenal and intrajejunal dai-kenchu-to-induced contracti ons was studied. Plasma motilin was measured by specific radioimmunoassay. Intraduodenal and intrajejunal dai-kenchu-to induced phasic contractions in the duodenum and proximal jejunum, respectively, and those contractions mi grated distally. Phasic contractions induced by intraduodenal and intrajeju nal daikenchu-to were inhibited by atropine and hexamethonium at all sites. Plasma motilin was not affected by dai-kenchu-to. Intraduodenal and intraj ejunal dai-kenchu-to stimulates upper gastrointestinal motility at and dist al to the administration sites through cholinergic receptors.