Xl. Jin et al., Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs, DIG DIS SCI, 46(6), 2001, pp. 1171-1176
The aim of the present study was to study the effect and mechanism of actio
n of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clini
cally effective for uncomplicated postoperative adhesive intestinal obstruc
tion, on upper gastrointestinal motility. Five mongrel dogs were equipped w
ith four strain-gauge force transducers on the antrum, duodenum, and proxim
al and distal jejunum to measure contractile activity. Dai-kenchu-to (0.5,
1.5, and 3.0 g) was administered into the duodenal or proximal jejunal lume
n. The effect of atropine, hexamethonium, phentolamine, propranolol, and on
dansetron on intraduodenal and intrajejunal dai-kenchu-to-induced contracti
ons was studied. Plasma motilin was measured by specific radioimmunoassay.
Intraduodenal and intrajejunal dai-kenchu-to induced phasic contractions in
the duodenum and proximal jejunum, respectively, and those contractions mi
grated distally. Phasic contractions induced by intraduodenal and intrajeju
nal daikenchu-to were inhibited by atropine and hexamethonium at all sites.
Plasma motilin was not affected by dai-kenchu-to. Intraduodenal and intraj
ejunal dai-kenchu-to stimulates upper gastrointestinal motility at and dist
al to the administration sites through cholinergic receptors.