Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer

Citation
K. Matsuo et al., Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer, CARCINOGENE, 22(6), 2001, pp. 913-916
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CARCINOGENESIS
ISSN journal
0143-3334 → ACNP
Volume
22
Issue
6
Year of publication
2001
Pages
913 - 916
Database
ISI
SICI code
0143-3334(200106)22:6<913:GIBAAD>2.0.ZU;2-Y
Abstract
Aldehyde dehydrogenase-2 (ALDH2) degrades acetaldehyde metabolized from eth ano. Its encoding gene ALDH2 has a functional polymorphism: ALDH2 GIu487Lys . An association between this polymorphism and esophageal cancer among alco holics has been reported. To further evaluate the gene-environment interact ion, a hospital-based case-control study was conducted. Cases were 102 pati ents with histologically confirmed esophageal cancer and controls were 241 non-cancer outpatients of Aichi Cancer Center, ALDH2 genotypes were examine d by a PCR-CTPP method developed in our laboratory, which does not require a digestion stage. Logistic regression analysis was employed for estimation of relative risk and gene-environment interaction, The allele frequency fo r ALDH2 Lys487 was 0.28, consistent with previous reports. The age, sex, sm oking and drinking status adjusted odds ratio for the ALDH2 Glu/Lys and Lys /Lys genotypes as compared with the Glu/Glu genotype was 3.43 (95% CI 1.74- 6.75). The odds ratio for heavy drinking was 49.6 (14.5-169.4) among Lys487 carriers and 7.84 (2.77-22.2) for the Glu/Glu genotype, The gene-environme nt interaction between alcohol drinking and the ALDH2 Lys487 allele,vas 6.8 4 (2.39-19.6), whereas no significant interaction was obtained with smoking status. Although limited because of its prevalent case-control design, our study revealed a strong gene-environment interaction between ALDH2 polymor phism and heavy alcohol consumption. Taking the observed high risk of esoph ageal cancer in association with the ALDH2 Lys487 allele into consideration , reducing alcohol intake may be most protective among Lys487 allele carrie rs of this polymorphism.