Novel cell lines established from a human myxoid malignant fibrous histiocytoma arising in the uterus

Citation
Y. Kiyozuka et al., Novel cell lines established from a human myxoid malignant fibrous histiocytoma arising in the uterus, CANC GENET, 127(1), 2001, pp. 7-15
Citations number
55
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
0165-4608 → ACNP
Volume
127
Issue
1
Year of publication
2001
Pages
7 - 15
Database
ISI
SICI code
0165-4608(200105)127:1<7:NCLEFA>2.0.ZU;2-I
Abstract
Two cell lines (Nara-H and Nara-F) with different phenotypes were establish ed from a myxoid MFH of the uterus. In vitro, Nara-F grew in sheets showing a storiform arrangement and Nara-H in raised colonies. Although tumors gen erated in nude mice shared similar morphological features of abundant myxoi d tumor in Nara-H and -F, the pleomorphic component was conspicuous in Nara -F. Both cell lines produced hyaluronic-acid but CD44 was expressed only in Nara-H. Estrogen receptor alpha (ER alpha) and progesterone receptor (PgR) were detected in Nara-H. Nara-F was positive for ER beta and PgR. Among ho rmonal agents, the response to the anti-estrogen tamoxifen was more sensiti ve than progesterone agents. This report illustrates the characteristics of these newly established cell lines, and presents the possibility of an adj uvant hormonal therapy for MFH. (C) 2001 Elsevier Science Inc.