Prospective study of antibody to human papilloma virus type 16 and risk ofcervical, endometrial, and ovarian cancers (United States)

Citation
M. Hisada et al., Prospective study of antibody to human papilloma virus type 16 and risk ofcervical, endometrial, and ovarian cancers (United States), CANC CAUSE, 12(4), 2001, pp. 335-341
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Envirnomentale Medicine & Public Health
Journal title
CANCER CAUSES & CONTROL
ISSN journal
0957-5243 → ACNP
Volume
12
Issue
4
Year of publication
2001
Pages
335 - 341
Database
ISI
SICI code
0957-5243(2001)12:4<335:PSOATH>2.0.ZU;2-2
Abstract
Objective: Human papilloma virus (HPV) is frequently detectable in cancers of the cervix, vagina, and vulva, but its role in endometrial and ovarian c ancers is less certain. This analysis aimed to examine the association of p resence of HPV type 16 (HPV-16) antibodies with subsequent risk of cervical , endometrial, and ovarian cancers. Methods: In a prospective study enrolling over 15,000 pregnant women, pre-c ancer sera from women who developed cervical (n = 83), endometrial (n = 34) , and ovarian (n = 35) cancers were compared with sera from 172 control wom en frequency-matched by age group and race. Results: HPV-16 seropositivity (OR = 2.0, 95% CI 1.0-3.4) was associated wi th cervical cancer, with the association more prominent for cancers occurri ng within 10 years of serum sampling (OR = 2.3, 95% CI 1.0-5.3) than cancer s occurring later (OR = 1.6, 95% CI 0.75-3.6). Overall, the associations be tween HPV-16 seropositivity and endometrial (OR = 1.6, 95% CI 0.64-3.8) and ovarian cancers (OR = 1.1, 95% CI 0.43-2.8) were not significant, although the odds ratios for those cancers occurring within 20 years after serum sa mpling were similar to that for cervical cancer (OR = 2.2 for both). Conclusions: Our results confirm that HPV-16 infection precedes the develop ment of cervical cancer. Predictability of HPV-16 seropositivity for risk o f other female cancers warrants further investigation.