Cream psoralen plus ultraviolet A therapy for granuloma annulare

Citation
M. Grundmann-kollmann et al., Cream psoralen plus ultraviolet A therapy for granuloma annulare, BR J DERM, 144(5), 2001, pp. 996-999
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dermatology,"da verificare
Journal title
BRITISH JOURNAL OF DERMATOLOGY
ISSN journal
0007-0963 → ACNP
Volume
144
Issue
5
Year of publication
2001
Pages
996 - 999
Database
ISI
SICI code
0007-0963(200105)144:5<996:CPPUAT>2.0.ZU;2-D
Abstract
Background Treatment modalities for granuloma annulare (GA) often remain un satisfactory or can be accompanied by potentially hazardous side-effects. P soralen plus ultraviolet (UV) A (PUVA) bath photochemotherapy has been repo rted to be highly effective in the treatment of GA. Another form of topical PUVA therapy, using 8-methoxypsoralen-containing cream or gel preparations , has been proven to be as effective as bath PUVA therapy in the treatment of palmoplantar dermatoses. Objectives To assess the efficacy of cream PUVA photochemotherapy in patien ts with GA. Methods Five patients with GA were treated. The diagnosis was confirmed by pretreatment skin biopsies. Cream PUVA therapy was performed four times a w eek: the mean number of treatments was 26 (range 17-40) and mean cumulative UVA dose was 55.9 J cm(-2) (range 18.2-109.2). Results Cream PUVA photochemotherapy induced significant clinical improveme nt (one patient) or clearance (four patients) of GA in all patients. Cleara nce was documented clinically and histopathologically. Conclusions Cream PUVA phototherapy can be highly effective in patients aff ected by localized forms of GA.