Background Treatment modalities for granuloma annulare (GA) often remain un
satisfactory or can be accompanied by potentially hazardous side-effects. P
soralen plus ultraviolet (UV) A (PUVA) bath photochemotherapy has been repo
rted to be highly effective in the treatment of GA. Another form of topical
PUVA therapy, using 8-methoxypsoralen-containing cream or gel preparations
, has been proven to be as effective as bath PUVA therapy in the treatment
of palmoplantar dermatoses.
Objectives To assess the efficacy of cream PUVA photochemotherapy in patien
ts with GA.
Methods Five patients with GA were treated. The diagnosis was confirmed by
pretreatment skin biopsies. Cream PUVA therapy was performed four times a w
eek: the mean number of treatments was 26 (range 17-40) and mean cumulative
UVA dose was 55.9 J cm(-2) (range 18.2-109.2).
Results Cream PUVA photochemotherapy induced significant clinical improveme
nt (one patient) or clearance (four patients) of GA in all patients. Cleara
nce was documented clinically and histopathologically.
Conclusions Cream PUVA phototherapy can be highly effective in patients aff
ected by localized forms of GA.